After trying several brand name pick up humbuckers, I settled on Stapleton Guitars Alnico 2 humbucker. I'm using it in a Stratocaster Squire guitar. It's an early Taiwanese made guitar with a 45 millimetre body so it's fairly hefty.
This pickup is great it takes as much distortion as can throw it and still comes out with clear single note definition.
I have the bridge wired in parallel series configuration and can switch from either.
The neck is in a single coil and series configuration.
With a good middle single coil pickup in place this guitar really sings like a sweet Strat.
I would fully recommend these pickups as they sound good and are around half the price of other commercially available pickups.